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Jeffrey R Keefer Selected Research

2,2-dimethylbutyric acid

11/2012A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease.
8/2011Evaluation of safety and pharmacokinetics of sodium 2,2 dimethylbutyrate, a novel short chain fatty acid derivative, in a phase 1, double-blind, placebo-controlled, single-dose, and repeat-dose studies in healthy volunteers.

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Jeffrey R Keefer Research Topics

Disease

6Sickle Cell Anemia (Hemoglobin S Disease)
12/2017 - 05/2008
3Thalassemia
11/2012 - 08/2011
2Pain (Aches)
10/2013 - 05/2008
2Malaria
01/2012 - 04/2011
1Hemoglobinopathies
08/2011
1Anemia
08/2011
1beta-Thalassemia (Cooley's Anemia)
08/2011
1Falciparum Malaria (Plasmodium falciparum Malaria)
04/2011
1Respiratory Insufficiency (Respiratory Failure)
05/2008
1Acute Chest Syndrome
05/2008
1Asthma (Bronchial Asthma)
05/2008

Drug/Important Bio-Agent (IBA)

4Fetal Hemoglobin (Hemoglobin F)IBA
10/2013 - 04/2011
3GlobinsIBA
11/2012 - 08/2011
22,2-dimethylbutyric acidIBA
11/2012 - 08/2011
1Sickle HemoglobinIBA
12/2017
1SodiumIBA
11/2012
1Hemoglobins (Hemoglobin)IBA
01/2012
1Immunoglobulin G (IgG)IBA
04/2011
1Dexamethasone (Maxidex)FDA LinkGeneric
05/2008
1Adrenal Cortex Hormones (Corticosteroids)IBA
05/2008

Therapy/Procedure

1Aftercare (After-Treatment)
05/2008